Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.
نویسندگان
چکیده
We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.
منابع مشابه
Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism.
A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
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عنوان ژورنال:
- Chemical communications
دوره 50 45 شماره
صفحات -
تاریخ انتشار 2014